Autoantibodies to glutamate, GABA And their receptors in epilepsy

Authors

  • L. A. Vetrile Institute of General Pathology and Pathophysiology, Moscow, Russia
  • M. N. Karpova Institute of General Pathology and Pathophysiology, Moscow, Russia
  • L. V. Kuznetzova Institute of General Pathology and Pathophysiology, Moscow, Russia

Keywords:

autoantibodies; glutamate; GABA, receptors; epilepsy

Abstract

This review discusses the pathogenic role of autoantibodies (autoAB) to excitatory and inhibitory neurotransmitters glutamate, GABA and their receptors in the pathogenesis of epilepsy. The data of clinical and experimental studies show that glutamate AMPA and NMDA- receptors autoAB and GABA receptors autoAB in high titers are highly pathogenic, causing a significant decrease of the density of the receptors and contribute the neuronal death. Discusses the results of experimental data about of the anticonvulsant action of glutamate antibodies (AT) and opposite proconvulsant effect of GABA antibodies in different models of epileptic activity.

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Published

2015-04-08

Issue

Vol. 59 No. 1 (2015)

Section

Reviews

How to Cite

[1]
2015. Autoantibodies to glutamate, GABA And their receptors in epilepsy. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 59, 1 (Apr. 2015), 94–102.

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