Current directions in development of postgenomic medical technologies

Abstract

The aim of this study was to analyze key expected postgenomic technologies as a part of priority in scientific and technological development defined in item 20 of the Strategy for Scientific and Technological Development of the Russian Federation, «Transition to personalized medicine, high-tech health care and health saving technologies through the rational use of medicines (primarily antibacterial)». Results. The most promising areas of further research were identified. The international level of postgenomic technologies (PGT) allows to move from research and development to implementation in medical practice. Presently, industrial biotechnology, biopharmaceuticals, including development of gene editing methods for treatment of oncological and orphan diseases and molecular profiling methods for individualized medicine, nutrition, and prolonging the active life are considered the main directions for successful practical use of PGT in Russia and other countries. Conclusion. Rapid development of high-performance postgenomic technologies and computer systems has expedited studying biological systems. Individual and integrative postgenomic profiles are useful for monitoring the state of human health, taking preventive measures, and selecting effective drug therapy.