Oxidative stress and the content of antioxidative factors in THE isolated brain perfused in situ USING A solution with A high oxygen tension

Authors

  • Evgeniy B. Tezikov I.M. Sechenov First Moscow State Medical University, Trubetskaya Str 8, Bldg. 2, Moscow 119991, Russia http://orcid.org/0000-0003-0517-3448
  • S. V. Pirozhkov I.M. Sechenov First Moscow State Medical University, Trubetskaya Str 8, Bldg. 2, Moscow 119991, Russia http://orcid.org/0000-0002-7116-3398
  • S. L. Karateev I.M. Sechenov First Moscow State Medical University, Trubetskaya Str 8, Bldg. 2, Moscow 119991, Russia
  • Litvitskiy , I.M. Sechenov First Moscow State Medical University, Trubetskaya Str 8, Bldg. 2, Moscow 119991, Russia

DOI:

https://doi.org/10.25557/0031-2991.2018.03.113-119

Keywords:

isolated brain, hyperbaric oxygenation, oxidative stress

Abstract

The aim. To evaluate intensity of lipid peroxidation and content of antioxidative factors in the isolated brain perfused with a solution without oxygen carriers. Methods. We used an original model of in situ rat brain perfusion using a solution with a high oxygen tension. Neither O₂ carriers nor a barometric chamber were used, i.e., the brain was perfused under normal external barometric pressure. Results. Survival time of the perfused brain (criteria: electrocorticogram amplitude >

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Published

2018-10-05

Issue

Vol. 62 No. 3 (2018)

Section

Methods

How to Cite

[1]
2018. Oxidative stress and the content of antioxidative factors in THE isolated brain perfused in situ USING A solution with A high oxygen tension. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 62, 3 (Oct. 2018), 113–119. DOI:https://doi.org/10.25557/0031-2991.2018.03.113-119.