The changes of plasma levels of soluble TNF- α and TNF-R1 ratio is a prognostic marker and key element of the stroke pathogenesis

Authors

  • S. P. Sergeeva The State Budgetary Educational Institution of Higher Professional Education First Moscow State Medical University. THEM. Sechenov RF Ministry of Health, 119992, Moscow, ul. Trubetskaya, 8, p. 2
  • P. F. Litvickiy The State Budgetary Educational Institution of Higher Professional Education First Moscow State Medical University. THEM. Sechenov RF Ministry of Health, 119992, Moscow, ul. Trubetskaya, 8, p. 2
  • I. D. Breslavich State budgetary educational institution of higher professional education Moscow State University. Mv Lomonosova, 119991 Moscow, Lenin Mountains, 1
  • M. M. Gultyaev State budgetary educational institution of higher professional education Moscow State Medical Dental University. A.I. Evdokimova

Keywords:

stroke pathogenesis, prognostic marker, sTNF-α, sTNF-R1

Abstract

The goal of the present study was to investigate the plasma levels of sTNF-α, sTNF-R1 in acute stroke patients, to study the relation between ones, the neurological stroke severity and functional disability. The investigations comprised 60 ischemic stroke patients, 25 patients form control group. Plasma levels of sTNF-α, sTNF-R1 were detected by means of ELISA. The conclusion of interaction of sTNF-α and tmTNF-R1 increases inflammatory and apoptotic brain tissue damage on the first day of stroke is drawn. On the 7-th and 21-st days of stroke sTNF-α realize a neuroprotective effect. The interaction sTNF-α and sTNF-R1 blockade of damage expansion. As the result, prognostic significance of sTNF-α/sTNF-R1 is showed.

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Published

2014-02-03

Issue

Vol. 58 No. 1 (2014)

Section

Original research

How to Cite

[1]
2014. The changes of plasma levels of soluble TNF- α and TNF-R1 ratio is a prognostic marker and key element of the stroke pathogenesis. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 58, 1 (Feb. 2014), 13–17.