Role of inflammation cytokines in forming and rupture of brain arterio-venous malformations

Authors

  • Vadim A. Byvaltsev Irkutsk State Medical University, Ministry of Health,1, Krasnoe Vosstanie str., Irkutsk, 664003, Russia; Railway Clinical Hospital on the station Irkutsk-Passazhirskiy of Russian Railways Ltd., 10, Botkina str., 664082, Irkutsk, Russia; Irkutsk Scientific Center of Surgery and Traumatology, 1, Bortsov Revolutsii str., 664003, Irkutsk, Russia; Irkutsk State Medical Academy of Continuing Education, 100, Yubileiniy Microdistrict, 664049, Irkutsk, Russia http://orcid.org/0000-0003-4349-7101
  • I. A. Stepanov Irkutsk State Medical University, Ministry of Health,1, Krasnoe Vosstanie str., Irkutsk, 664003, Russia http://orcid.org/0000-0002-2592-4512
  • N. A. Tetyushkin Irkutsk State Medical University, Ministry of Health,1, Krasnoe Vosstanie str., Irkutsk, 664003, Russia http://orcid.org/0000-0003-3828-8743
  • M. A. Shameeva Irkutsk State Medical University, Ministry of Health,1, Krasnoe Vosstanie str., Irkutsk, 664003, Russia http://orcid.org/0000-0002-3085-2998
  • M. A. Aliyev Irkutsk State Medical University, Ministry of Health,1, Krasnoe Vosstanie str., Irkutsk, 664003, Russia http://orcid.org/0000-0002-5995-3194

DOI:

https://doi.org/10.25557/0031-2991.2018.04.185-194

Keywords:

is of cAVM rupture. The review presents experimental studies conducted worldwide and focusing on the influence of genetic factors and proinflammatory cytokines on cAVM development, progression and rupture. The authors provided modern molecular therapeutic approaches to the treatment of cAVM. The topical, still unsolved issues were identified, which warrant further experimental and clinical studies on the treatment of this nosological form

Abstract

This review analyzes current reports on the pathogenetic role of inflammatory cytokines in formation and rupture of cerebral arteriovenous malformations (cAVM). The authors analyzed reports from PubMed, MedLine, and eLibrary databases that addressed the role of inflammatory cytokines in the molecular pathogenesis of cAVM formation and rupture. The cAVM rupture leading to intracranial hemorrhage is the most frequent and formidable clinical manifestation resulting in persistent neurologic deficits, early disability, and death. In the pathogenesis of cAVM development, an important role belongs to the inflammatory process, which induces thinning of the vascular wall. Relationships were found between some genetic polymorphisms that enhance expression of a number of angiogenic and proinflammatory factors that play a key role in the

Published

2018-11-21

Issue

Vol. 62 No. 4 (2018)

Section

Reviews

How to Cite

[1]
2018. Role of inflammation cytokines in forming and rupture of brain arterio-venous malformations. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 62, 4 (Nov. 2018), 185–194. DOI:https://doi.org/10.25557/0031-2991.2018.04.185-194.