Morphological study of neuroprotective properties of dipeptide mimetic of nerve growth factor (GK-2h) in focal ischemic damage of rat brain prefrontal cortex

Authors

  • I. V. Barskov Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • E. V. Stelmashuk Research Center of Neurology RAMS, 80, Volokolamskoye hwy., Moscow, 125367, Russia
  • G. A. Romanova Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • L. G. Khaspekov Research Center of Neurology RAMS, 80, Volokolamskoye hwy., Moscow, 125367, Russia

Keywords:

nervous growth factor mimetic, bifocal photoinduced ischemia, rat brain prefrontal cortex, neuroprotection

Abstract

The neuroprotective effects of dipeptide GK-2h, a mimetic of nerve growth factor, in bifocal photoinduced ischemia in rat brain prefrontal cortex was studied. It was shown that GK-2h, injected intraperitonealy in dose 0,1 mg/kg in 1 h or 4 h after operation and then on 2-nd, 4-th and 8-th days, prevented significantly on 9-th day from increasing volume of cortical infarction.

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Published

2013-11-29

Issue

Vol. 57 No. 4 (2013)

Section

Original research

How to Cite

[1]
2013. Morphological study of neuroprotective properties of dipeptide mimetic of nerve growth factor (GK-2h) in focal ischemic damage of rat brain prefrontal cortex. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 57, 4 (Nov. 2013), 17–20.

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