Neuroprotective and antiamnestic effects of mutant molecules of erythropoietin on model of photochemical thrombosis of rat brain prefrontal cortex

Authors

  • F. M. Shakova Institute of General Pathology and Pathophysiology, Moscow
  • T. I. Kalinina State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow
  • M. V. Gulyaev Faculty of Fundamental Medicine, Moscow State University n.a. M.V. Lomonosov
  • A. M. Cheremnykh State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow
  • V. L. Yurin State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow
  • G. A. Romanova Institute of General Pathology and Pathophysiology, Moscow

Keywords:

photothrombosis; the prefrontal cortex; mutant erythropoietin molecules MEPO-TR, MEPO-Fc; intranasal administration; MRI; PA; neuroprotective and antiamnestic effect.

Abstract

Mutant EPO molecules, deprived of erythropoietic activity, but possessing cytoprotective action, were created by the method of genetic engineering. The assessment of the therapeutic effectiveness of the received mutant proteins was carried out by the retention of the conditioned reflex of passive avoidance (PA), developed before the ischemic injury of rat brain prefrontal cortex, and by the MRI-analysis of ischemic damage volume. Antiamnestic and neuroprotective action of mutant molecules – MERO-Fc and MEPO-TR is investigated on model of photothrombosis of rat brain prefrontal cortex at single intranasal introduction in 1 h after cortex ischemic damage. The neuroprotective (MRI) and antiamnestic (PA) effects of mutant molecules of erythropoietin derivatives are shown.

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Published

2016-03-22

Issue

Vol. 60 No. 4 (2016)

Section

Original research

How to Cite

[1]
2016. Neuroprotective and antiamnestic effects of mutant molecules of erythropoietin on model of photochemical thrombosis of rat brain prefrontal cortex. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 60, 4 (Mar. 2016), 34–38.

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