Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats

Abstract

The aim of the present work was an estimation of effects of chronic administration of selective serotonin reuptake inhibitors — fluoxetine (5,0 mg/kg, p.o.) and paroxetine (5,0 mg/kg, p.o.) for 14 days of postnatal period on anxiety-like behavior in the prenatally stressed male rats during pubertat period (1,5 month) and the adult state (3 month). Chronic paroxetine administration to females failed to change an anxiety-like behavior independently from age. On the contrary, administration of fluoxetine resulted in modulating influence on the anxiety-like behavior of prenatally stressed rats dependently from age: anxiolytic effect was noted in young males, while anxiogenic effect was observed in the adult male rats.