Homocysteine metabolism in experimental models of hyperhomocysteinemia in rodents. Part 1: genetic models.

Authors

DOI:

https://doi.org/10.25557/0031-2991.2020.04.118-124

Keywords:

homocysteine, hyperhomocysteinemia, modeling, metabolism, methionine S-adenosylhomocysteine

Abstract

Modeling hyperhomocysteinemia in rodents is a common way to study the role of homocysteine in pathogenesis of various diseases (myocardial infarction, stroke, cognitive impairment, Alzheimer’s disease, kidney failure, etc.). This review focuses on biochemical aspects of homocysteine metabolism, genetic methods for modeling hyperhomocysteinemia in rats and mice, and effects of these models on metabolism of both homocysteine itself and related metabolites (methionine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine).

Author Biographies

  • A.V. Ivanov, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia
    .
  • E.D. Virus, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia
    .
  • V.I. Loginov, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia
    .
  • I.S. Zimina, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia
    .
  • A.M. Burdennyy, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia
    .
  • V.V. Alexandrin, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia
    .
  • A.A. Kubatiev, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, 125315, Russia; Russian Medical Academy of Continuous Professional Education, Barrikadnaya Str., 2/1, bld. 1, Moscow, 125993, Russia
    .

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Published

2020-11-26

Issue

Vol. 64 No. 4 (2020)

Section

Reviews

How to Cite

[1]
2020. Homocysteine metabolism in experimental models of hyperhomocysteinemia in rodents. Part 1: genetic models. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 64, 4 (Nov. 2020), 118–124. DOI:https://doi.org/10.25557/0031-2991.2020.04.118-124.

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