Polymorphism of methylenetetrahydrofolate reductase (MTHFR) folate metabolism gene and hyperhomocysteinemia in migraine

Authors

  • Z.G. Tadtaeva Saint Petersburg State Pediatric Medical University, 2 Litovskaya St., 194100 Saint Petersburg, Russian Federation
  • E.E. Yakovleva Saint Petersburg State Pediatric Medical University, 2 Litovskaya St., 194100 Saint Petersburg, Russian Federation; Institute of Experimental Medicine, 12 Akad. Pavlova, 197376 Saint Petersburg, Russian Federation https://orcid.org/0000-0002-0270-0217
  • A.V. Amelin Academician I.P. Pavlov First Saint Petersburg State Medical University, 6-8 L’va Tolstogo St, 197022 Saint Petersburg, Russian Federation

DOI:

https://doi.org/10.25557/0031-2991.2021.04.109-115

Keywords:

methylenetetrahydrofolate reductase (МТHFR), migraine, folate cycle genes, homocysteine, hyperhomocysteinemia, targeted therapy

Abstract

The review discusses the role of polymorphism of the methylenetetrahydrofolate reductase (MTHFR) folate metabolism gene responsible for hyperhomocysteinemia in the pathogenesis of migraine. Data on the polymorphism of the folate cycle gene C677 and homocysteine metabolism are presented. The pathogenetic mechanism of migraine associated with proinflammatory, procoagulant properties of homocysteine and with the activation of oxidative stress, endothelial dysfunction, and neurogenic inflammation related with increased concentrations of homocysteine is described. Prospects and social significance of implementing data of genetic research into clinical practice are discussed. Included is the role of genetic research in predicting the course and complications of migraine, in assessment of risk for complications, and in pharmacotherapeutic approaches to migraine treatment. Methods. MEDLINE, SCOPUS and Web of Science databases were used to search for data: MTHFR, migraine, pathophysiology, hyperhomocysteinemia, targeted therapy.

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Published

2021-12-11

Issue

Vol. 65 No. 4 (2021)

Section

Reviews

How to Cite

[1]
2021. Polymorphism of methylenetetrahydrofolate reductase (MTHFR) folate metabolism gene and hyperhomocysteinemia in migraine. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 65, 4 (Dec. 2021), 109–115. DOI:https://doi.org/10.25557/0031-2991.2021.04.109-115.

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