Signaling mechanism of neuroprotective effect of ischemic preconditioning of brain

Authors

  • L.N. Maslov Scientific Research Institute of Cardiology of SB of RAMS, 111a, Kievskaja str., Tomsk, 634012, Russia; Tomsk State Pedagogical University, 60, Kievskaya str., Tomsk, 634061, Russia

Keywords:

brain, ischemia, reperfusion, preconditioning, signaling mechanism

Abstract

Analysis of published data indicates that Ras-protein and kinases PI3K, Akt, MEK1/2, ERK1/2, PKC, CaMKII are involved in the signaling mechanism of ischemic preconditioning. In addition, it is established that cyclooxigenase-2, NO-synthase and mitKATP-channel are involved in delayed preconditioning. Signaling mechanism of early ischemic preconditioning of brain is remained unstudied.

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Published

2013-08-12

Issue

Vol. 57 No. 3 (2013)

Section

Reviews

How to Cite

[1]
2013. Signaling mechanism of neuroprotective effect of ischemic preconditioning of brain. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 57, 3 (Aug. 2013), 73–80.