Experimental therapy of cardiac remodeling with quercetin-containing drugs

Authors

  • M.A. Kuzmenko Bogomoletz Institute of Physiology, 4, Bogomoletz str., Kyiv, 01024, Ukraine
  • V.B. Pavlyuchenko Bogomoletz Institute of Physiology, 4, Bogomoletz str., Kyiv, 01024, Ukraine
  • L.V. Tumanovskaya Bogomoletz Institute of Physiology, 4, Bogomoletz str., Kyiv, 01024, Ukraine
  • V.E. Dosenko Bogomoletz Institute of Physiology, 4, Bogomoletz str., Kyiv, 01024, Ukraine
  • A.A. Moybenko Bogomoletz Institute of Physiology, 4, Bogomoletz str., Kyiv, 01024, Ukraine

Keywords:

cardiac remodeling, bioflavonoids, fibrosis, cardiac function

Abstract

It was shown that continuous beta-adrenergic hyperstimulation resulted in cardiac function disturbances and fibrosis of cardiac tissue. Treatment with quercetin-containing drugs, particularly, water-soluble corvitin and tableted quertin exerted favourable effect on cardiac hemodynamics, normalized systolic and diastolic function in cardiac remodeling, induced by sustained beta-adrenergic stimulation. It was estimated that conducted experimental therapy limited cardiac fibrosis area almost three-fold, that could be associated with first and foremost improved cardiac distensibility, characteristics of diastolic and also pump function in cardiac remodeling.

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Published

2013-06-19

Issue

Vol. 57 No. 2 (2013)

Section

Original research

How to Cite

[1]
2013. Experimental therapy of cardiac remodeling with quercetin-containing drugs. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 57, 2 (Jun. 2013), 17–22.