Oxidative stress and parameters of spermatogenesis in men with idiopathic infertility before and after the treatment with ethylmethylhydroxypyridine malate

Abstract

Abstract. Oxidative stress (OS) is now recognized as an important factor contributing to the development of various forms of male infertility, including idiopathic. Modern studies are characterized by high heterogeneity and convincing conclusions regarding the effect of antioxidants (AO) on ejaculate parameters have not yet been presented. Aim of the study: to evaluate changes in the main parameters of the ejaculate and the state of the LPO-AOP system when using ethylmethylhydroxypyridine malate in men with idiopathic infertility. Methodology. A retrospective analysis of the results of examination of men (n=225) from infertile couples was carried out and men with idiopathic infertility were identified. A control group of practically healthy men with realized reproductive function was formed. Ejaculate studies were carried out in accordance with WHO recommendations (2022). Determination of indicators of the lipid peroxidation system and antioxidant protection was carried out in the ejaculate using generally accepted spectrophotometric foluorometric methods. Results. After a month of taking the drug ethylmethylhydroxypyridine malate, an increase in the number of sperm with progressive motility was found in the sperm of infertile men, in contrast to patients who did not take this drug. In the ejaculate of men who did not take the antioxidant drug, no significant changes in the indicators of the LPO-AOP system were detected. After taking an antioxidant drug in the ejaculate of men with idiopathic infertility, a statistically significant decrease in LPO indicators is observed against the background of an increase in the power of the antioxidant system, expressed in a significant increase in the level of SOD and AOA. Conclusion. Thus, as a result of the study, it was established that the antioxidant drug ethylmethylhydroxypyridine malate has an activating effect on the concentration and motility of sperm, and also reduces oxidative processes in the ejaculate of men with idiopathic infertility.