Mechanisms of cardiovascular resistance to injury in post-traumatic stress disorder

Authors

  • Evgeniya Borisovna Manukhina Institute of General Pathology and Pathophysiology, 8 Baltiyskaya St., Moscow, 125315, Russian Federation; University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth 76107, USA
  • Marina Vladislavovna Kondashevskaya «Avtsyn Research Institute of Human Morphology» of Federal State Budgetary Scientific Institution «Petrovsky National Research Centre of Surgery», 3 Tsyurupy St., Moscow 117418, Russian Federation
  • Olga Petrovna Budanova Institute of General Pathology and Pathophysiology, 8 Baltiyskaya St., Moscow, 125315, Russian Federation https://orcid.org/0000-0002-6650-5082
  • Vadim Eduardovich Tseilikman South Ural State University (National Research University), 76 Prosp. Lenina, Chelyabinsk, 454080, Russian Federation; Novosibirsk National Research State University, 1 Pirogov St., Novosibirsk, 630090, Russian Federation; Chelyabinsk State University, 129 Bratyev Kashirinykh St., Chelyabinsk, 454001, Russian Federation https://orcid.org/0000-0003-2935-7487
  • Harry Fred Downey University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth 76107, USA

DOI:

https://doi.org/10.48612/pfiet/0031-2991.2025.02.97-107

Keywords:

post-traumatic stress disorder, cardiovascular system, resistance, inflammation, oxidative stress, hypothalamic-pituitary-adrenal system, hemostasis

Abstract

Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder that develops in people who have experienced traumatic events. PTSD often induces cardiovascular diseases and is their predictor and independent risk factor. Although approximately 50 to 84% of people experience severe, traumatic events during their lifetime, most of them do not develop chronic PTSD. The review summarizes experimental and clinical reports on the mechanisms of cardiovascular resistance to PTSD, which can help developing methods to enhance PTSD resilience in high-risk groups.

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Published

2025-06-22

Issue

Vol. 69 No. 2 (2025)

Section

Reviews

How to Cite

[1]
2025. Mechanisms of cardiovascular resistance to injury in post-traumatic stress disorder. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 69, 2 (Jun. 2025), 97–107. DOI:https://doi.org/10.48612/pfiet/0031-2991.2025.02.97-107.