Comparison of the effects of glutamate antibodies on neuronal activity of caspase 3 and memory impairment in rats induced by injection of Αβ₂₅₋₃₅ into the Meynert nuclei

Abstract

In experiments on rats showed that intranasal administration of glutamate antibodies in a dose of 300 μg/kg after 1 h after bilateral injection of neurotoxic fragment of β-amyloid protein (25-35) — Αβ25-35 — into the Meynert nuclei restores learning ability in the test of passive avoidance on 3 and 14 days of the experiment. Antibodies to glutamate decrease significantly increasing caspase 3 activity, detected on Day 3 after injection of Αβ25-35, in samples of the prefrontal cortex and hippocampus but not hypothalamus. Intranasal administration of γ-globulin had no effect on the performance of violations of mnestic functions and caspase 3 activity.