The changes in the biochemical indices of blood in cobalt intoxication on the background of the regulators of the expression of endothelial NO-synthase

Authors

  • S. G. Dzugkoev Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • I. V. Mozhayeva Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • L. B. Gigolaeva North Ossetian State Medical Academy, Vladikavkaz, Russian Federation
  • A. I. Tedtoeva Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • O. I. Margieva Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • F. S. Dzugkoeva Institute of Biomedical Research, Vladikavkaz, Russian Federation

Keywords:

oxidative stress, nitric oxide, cobalt chloride, L-arginine, L-NAME, NOS-3

Abstract

On the background of chronic cobalt intoxication in rats develops oxidative stress. This is accompanied by a decrease in the content of total metabolites of nitric oxide in the blood serum. The reasons for lower levels of the vasodilatation factor are the following: a deficiency of L-arginine and the increase in the content of the inhibitor of NOS-3. We found a decrease in the bioavailability of nitric oxide due to the increase in the content of oxidized low density lipids, total cholesterol and cholesterol-lowering lipids high density.

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Published

2014-12-05

Issue

Vol. 58 No. 4 (2014)

Section

Original research

How to Cite

[1]
2014. The changes in the biochemical indices of blood in cobalt intoxication on the background of the regulators of the expression of endothelial NO-synthase. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 58, 4 (Dec. 2014), 66–70.