Adaptive function of the brain and problems of hypoxia

Authors

  • Yu.S. Mednikova Institute of Higher Nervous Activity and Neurophysiology RAS, 5A, Butlerov street, Moscow, 117485, Russia
  • S.N. Koghechkin Institute of Pharmacology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • F.V. Kopytova Research Center of Neurology RAMS, 5, Obukha lane, Moscow, 105064, Russia
  • O.Kh. Koshtojantz Institute of Higher Nervous Activity and Neurophysiology RAS, 5A, Butlerov street, Moscow, 117485, Russia

Keywords:

cortical neurons, spontaneous activity, acetylcholine, temperature, hypoxia

Abstract

Based on the findings of various authors and own experimental data it was concluded that adaptive behaviour is regulated by changing in the level of spontaneous neuronal activity. Spontaneous firing is monitored by brain metabolic M-cholinergic reaction which increased the efficacy of dendritic propagation by mechanism of K+ membrane channels blockade. High energy demands of cholinergic process creates a threat to nerve cells survival in hypoxic conditions.

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Published

2012-08-22

Issue

Vol. 56 No. 3 (2012)

Section

Problema

How to Cite

[1]
2012. Adaptive function of the brain and problems of hypoxia. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 56, 3 (Aug. 2012), 33–41.