The comparison of antiamnestic action of antibodies to glutamate and neuropeptide Semax in the focal ischemic damage of prefrontal cortex of rat brain

Authors

  • G.A. Romanova Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
  • F.M. Shakova Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
  • T.V. Davudova Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia

Keywords:

bilateral photothrombosis, prefrontal cortex, peptide semax, AB-Glu, intranasal injection

Abstract

It was stated, that with bilateral photochemically induced thrombosis of the prefrontal cortex peptide semax and the AB-Glu by intranasal injection provoke pronounced neuroprotective and antiamnestic action. Intranasal injection semax (250 mkg/kg/daily during six postoperative days) and AB-Glu (250 mkg/kg in 1 hour after phototrombosis) demonstrate diminishing of cortex damage volume and relieve preservation and reproduction rat passive avoidance reflex, acquired before bilateral photochemically induced thrombosis of prefrontal cortex.

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Published

2012-12-20

Issue

Vol. 56 No. 3 (2012)

Section

Original research

How to Cite

[1]
2012. The comparison of antiamnestic action of antibodies to glutamate and neuropeptide Semax in the focal ischemic damage of prefrontal cortex of rat brain. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 56, 3 (Dec. 2012), 62–67.