Pathological changes after brain ischemia are similar to those observed in Alzheimer disease

Authors

  • D. N. Silachev Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation
  • V. N. Manskikh Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russian Federation
  • M. V. Gulyaev Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russian Federation
  • I. B. Pevzner Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation
  • L. D. Zorova International Laser Center, Lomonosov Moscow State University, Moscow, Russian Federation
  • V. A. Babenko Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russian Federation
  • E. Y. Plotnikov Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation
  • Y. A. Pirogov Faculty of Physics Lomonosov Moscow State University, Moscow, Russian Federation
  • D. B. Zorov Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation

Keywords:

brain ischemia, Alzheimer’s disease, dementia, senile plaques, tau-protein

Abstract

We studied the influence of ischemia/reperfusion of the middle cerebral artery in the rat’s brain on the deferred violation of cognitive functions of the brain which are similar to main symptoms observed in the development of Alzheimer’s disease. Using 8-hose radial labyrinth we demonstrated that 6 months after incidence of cerebral ischemia a significant impairment of working memory and a decrease in animals the ability to learn are developed. 7 months after focal cerebral ischemia we could observe the accumulation of a mature amyloid peptide and hyperphosphorylated form of the Tau protein in ipsilateral cerebral hemisphere and of the the beta-amyloid peptide precursor in the contralateral hemisphere. Thus, after an experimental stroke in the brain pathological changes occur, as those typical of Alzheimer’s disease.

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Published

2014-12-05

Issue

Vol. 58 No. 4 (2014)

Section

Original research

How to Cite

[1]
2014. Pathological changes after brain ischemia are similar to those observed in Alzheimer disease. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 58, 4 (Dec. 2014), 53–58.