Administration of extracellular vesicles from bone marrow cells promotes recovery of physiological parameters in irradiated mice

Authors

  • I. B. Alchinova Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation; Research Institute for Space Medicine of the Federal Scientific and Clinical Center of Specialized Medical Assistance and Medical Technologies of the Federal Biomedical Agency of Russia, Orekhovyi Blvd. 28, Moscow 115682, Russian Federation
  • MargaritaVyacheslavovna V. Polyakova Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
  • E. N. Yakovenko Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
  • Yu. S. Medvedeva Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
  • I. N. Saburina Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation
  • M. Yu. Karganov Institute of General Pathology and Pathophysiology, Baltijskaya Str. 8, Moscow 125315, Russian Federation

DOI:

https://doi.org/10.25557/0031-2991.2018.04.237-240

Keywords:

extracellular vesicles, multipotent mesenchymal stromal cells, gamma-irradiation

Abstract

Extracellular vesicles secreted by human multipotent mesenchymal stromal cells were injected intravenously into mice one week after irradiation at a sublethal dose. At 3 and 6 weeks after the start of the experiment, changes in physiological parameters provoked by the irradiation and therapy were evaluated. The following methods of evaluation were used: measurement of body weight, laser correlation spectroscopy, white blood cell count, laser flow cytometry, histological examination of internal organs. The study showed that a single intravenous injection of the analyzed extracellular vesicles into irradiated animals helped to reduce severity of the changes caused by a high dose of gamma radiation.

Published

2018-11-21

Issue

Vol. 62 No. 4 (2018)

Section

Brief Reports

How to Cite

[1]
2018. Administration of extracellular vesicles from bone marrow cells promotes recovery of physiological parameters in irradiated mice. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 62, 4 (Nov. 2018), 237–240. DOI:https://doi.org/10.25557/0031-2991.2018.04.237-240.

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