Urgent changes in the expression of hypoxia-inducible factor-1a (HIF-1a) in the neocortex of rats with different tolerance to acute hypoxia underwent focal ischemic stroke prefrontal cortex

Authors

  • Yu. I. Kirova Institute of general pathology and pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • Fatimat M. Shakova Institute of general pathology and pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • Elita L. Germanova Institute of general pathology and pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • Alexander А. Paltsyn Institute of general pathology and pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • Galina А. Romanova Institute of general pathology and pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • Yelena А. Rybnikova Pavlov Institute of physiology RAS, 6, Makarova str., St.Peterburg, 199034, Russia
  • Ludmila D. Lukyanova Institute of general pathology and pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia

Keywords:

rat brain prefrontal cortex, photothrombosis, HIF-1a expression, tolerance to hypoxia

Abstract

Using immunohistochemical method, it was demonstrated that neurons of the cerebral cortex have the capacity to express hypoxia-inducible factor-1 alpha (HIF-1a) in normoxia. Intensity of this process is different for rats having unequal tolerance to hypoxia. Basal HIF-1a expression in neurons of rats with low-resistance (LR) to hypoxia is higher compared to rats with high-resistance (HR). Bilateral photochemically induced focal ischemic insult in the rat prefrontal cortex completely suppressed HIF-1a neuronal expression the in the ischemic zone and only partially — in the area of the penumbra. Neuronal injury was more pronounced in cortex of LR rats compared to HR rats. These findings suggest that functional significance of HIF-1a is greater in neurons of the cerebral cortex of LR rats compared to HR rats.

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Published

2014-09-12

Issue

Vol. 58 No. 3 (2014)

Section

Original research

How to Cite

[1]
2014. Urgent changes in the expression of hypoxia-inducible factor-1a (HIF-1a) in the neocortex of rats with different tolerance to acute hypoxia underwent focal ischemic stroke prefrontal cortex. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 58, 3 (Sep. 2014), 9–16.